科研项目：
1.“PPTase辅基化网络及影响链霉菌聚酮类农药高效生物合成的代谢调控机制研究”国家自然科学基金区域联合重点（U24A20408），202501-202812，主持人
2.“有害生物侵染作物后招募防御微生物的发掘与应用基础研究”国家自然科学基金重点项目（32030090），202101-202512，主持人
3.“促进寒地水稻直播发芽出苗有益微生物和活性化合物研究”黑龙江自然科学基金研究团队项目（TD2022C002），2023.01-2026.12，主持人
4.“有害生物侵染作物后招募防御微生物的发掘与应用基础研究”国家自然科学基金重点项目（32030090），2021.01-2025.12，主持人
5.“新型植物生长调节剂五谷丰素早期应答基因及调控代谢通路研究”国家自然科学基金面上项目（31872037），2019.01-2022.12，主持人
6.“S. avermitilis neau1069全基因组鉴定代谢杀虫剂多拉菌素调控基因及调控机理研究”国家自然科学基金面上项目（31672092），2017.01-2020.12，主持人
7.“微生物天然产物农药创制创新团队”农业部农业科研杰出人才及创新团队，2015年。
8.长江学者（特聘教授），农药科，2014年。
9.“大豆根内特异微生物及疫霉病菌侵染后根招募微生物代谢活性化合物研究”国家自然科学基金面上项目（31471832），2015.01-2018.12，主持人
10.“微生物天然产物农药”国家自然科学杰出青年基金（31225024），2013.01-2016.12，主持人。
11.国家“万人计划”，科技部“中青年科技创新领军人才”，2012年。
12.“Streptomyces avermitilis neau1069生物合成多拉菌素（Doramectin）基因簇克隆和关键基因功能分析”国家自然科学基金面上项目（31071750），2011.01-2013.12，主持人。
论文著作：
1.Wei-shan Wang , Shan-shan Li , Zi-long Li, Jing-yu Zhang, Ke-qiang Fan, Gao-yi Tan , Guo-min Ai, Sin-Man Lam, Guang-hou Shui, Zhi-heng Yang, Hong-zhong Lu, Pin-jiao Jin, Yi-hong Li, Xiang-yin Chen, Xue-kui Xia, Xue-ting Liu, H. Kathleen Dannelly, Chen Yang, Yi Yang , Si-liang Zhang, Gil Alterovitz, Wen-sheng Xiang*，Li-xin Zhang*. Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces. Nat Biotechnol. 2020,38(1).
2.Shi Haoran,Wang Jiabin,Li Shanshan,Liu Chongxi,Li, Lei,Dong Zhuoxu,Ye, Lan,Wang Xiangjing,Zhang Yanyan,Xiang Wensheng, Coordinated regulation of two LacI family regulators, GvmR and GvmR2, on guvermectin production in Streptomyces caniferus,SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2024, 10(1):237-246
3.Song Wenshuai, Yu Xiaoyan, Yu Xiaoxin, Zhang Haifeng, Zhang Kuan, Guo Lifeng, Wang Ji-Dong, Tian Dong-Lan, Yu Qingtao, Wang Xiangjing, Zhao Junwei, Xiang Wensheng, Antifungal Activity and Potential Mechanisms of Two Bafilomycin Analogues Isolated from Streptomyces sp. NEAU-Y11 against Colletotrichum orbiculare,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2025, 73(19): 11814-11828
4.Bing Hui, Gu Jinzhao, Xia Banghua, Kong Xinyu, Luo Yanfang, Wang Xiangjing, Liu Chongxi, Zhao Junwei, Xiang Wensheng, Endophytic fungus Stagonosporopsis ajaci NEAU-BLH1 from Adonis amurensis enhances seed germination under low-temperature stress and increases grain yield in direct-seeded rice,MICROBIOLOGICAL RESEARCH, 2025, 295:128111
5.Wang Han, Ling Ling, Song Wenshuai, Gu Jinzhao, Bing Hui, Sun Jingzheng, Guo Lifeng, Luo Yanfang, Qi Huan, Wang Xiangjing, Wang Ji-Dong, Zhao, Junwei, Xiang Wensheng, Discovery of (+)-Methyl Nonactate as a Potential Fungicide against Gummy Stem Blight,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2025, 73(9):5248-5259
6.Zhang Kuan, Yu Xiaoyan, Yang, Xinru, Yang Zhiqi, Zhang Yan, Liu Jiayi, Wang Xiangjing, Zhao Junwei, XiangWensheng, Biocontrol potential and mechanism of a seed-endophytic Bacillus velezensis NEAU-HLD-9 against gray mold in green beans, FOOD MICROBIOLOGY, 2025, 136:105018
7.Yu Xiaoyan, Zhang Kuan, Yang Zhiqi, Guo Bowen, Yang Xinru, Zhang Yan, Liu Jiayi, Zhao,Zhenhua, Wang Xiangjing, Zhao Junwei, Xiang Wensheng, Biocontrol effect of Bullera alba PGY-2 on postharvest black spot of pear and insights into the associated defense mechanisms,POSTHARVEST BIOLOGY AND TECHNOLOGY, 2025, 234:114094
8.Song Wenshuai, Sun Jingzheng, Zhang Haifeng, Wang Han, Guo Lifeng, Fan Xiaoya, Xu Xi, Zhang Kun, Pang Hongbo, Wang Xiangjing, Zhao Junwei, Xiang Wensheng,9-Methylstreptimidone: A novel promising fungicide disrupting material metabolism and energy synthesis in Colletotrichum orbiculare,PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 2025, 215:106683
9.Liu Chongxi, Zhang Manman, Li Lei, Wang Xiangjing, Li Shanshan, Xiang Wensheng, Development and Application of the Novel Plant Growth Regulator Guvermectin: A Perspective,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 72(15):8365-8371
10.Yu Xiaoyan, Zhang Kuan, Liu Jiayi, Zhao Zhenhua, Guo Bowen, Wang Xiangjing, Xiang Wensheng, Zhao Junwei, Identification and evaluation of an endophytic antagonistic yeast for the control of gray mold (Botrytis cinerea) in apple and mechanisms of action, FOOD MICROBIOLOGY, 2024,123:104583
11.Zhao Li, Qian Lulu, Guo Lifeng, Lin Jiaying, Song Wenshuai, Yu Xiaoyan, Wang Xiangjing, Xiang Wensheng, Zhao Junwei, Enhancing cellulose and hemicellulose degradation in wheat straw composting by inoculation with Glycomyces: key factors and microbial community dynamics,ENVIRONMENTAL TECHNOLOGY,
12.Liu Chongxi, Li Chenxu, Bing Hui, Zhao Junwei, Li Lei, Sun Peng, Li Tingting, Du Dandan, Zhao Junlei, Wang Xiangjing, Xiang Wensheng, Integrated Physiological, Transcriptomic, and Metabolomic Analysis Reveals the Mechanism of Guvermectin Promoting Seed Germination in Direct-Seeded Rice under Chilling Stress,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2023, 71(19):7348-7358
13.Zhi-yinYu,Jian-PingHuang,JingYang,Chong-xiLiu,Yi-junYan,LiWang,Jun-weiZhao,YinChen,Wen-shengXiang*,Sheng-XiongHuang*,Discovery and biosynthesis of karnamicins as angiotensin converting enzyme inhibitors.Nat. Commun. 2023, DOI:10.1038/s41467-023-35829-1
14.Chong-xiLiu,Zhi-yanWang,YinChen,Yi-junYan,LeiLi,Yong-JiangWang, LuBai,Shan-shanLi,Yan-yanZhang,Xiang-jingWang, Sheng-xiongHuang*,Wen-shengXiang*.Guvermectin Biosynthesis Revealing the Key Role of a Phosphoribohydrolase and Structural Insight into the Active Glutamate of a Noncanonical Adenine Phosphoribosyltransferase. ACS Chemical Biology. 2023, DOI:10.1021/acschembio.2c00739.
15.Chong-xi Liu, Lu Bai, Peng Cao, Shan-shan Li, Sheng-xiong Huang, Ji-dong Wang, Lei Li, Ji Zhang, Jun-wei Zhao, Jia Song, Peng Sun, Yan-yan Zhang, Hui Zhang, Xiao-wei Guo, Xi-lang Yang, Xin-qiu Tan, Wen-de Liu, Wang, Xiang-jing Xiang*, Wen-sheng Xiang*. Novel Plant Growth Regulator Guvermectin from Plant Growth- Rhizobacteria Boosts Biomass and Grain Yield in Rice.J. Agric. Food Chem.2022, DOI:10.1021/acs.jafc.2c07072.
16.Chuan-yu Han#, Zhi-yin Yu#, Yu-ting Zhang, Zhi-yan Wang, Jun-wei Zhao, Sheng-Xiong Huang, Zhong-hua Ma, Zi-yue Wen, Chong-xi Liu*, Wen-sheng Xiang*. Discovery of Frenolicin B as Potential Agrochemical Fungicide for Controlling Fusarium Head Blight on Wheat. J. Agric. Food Chem. 2021：69 (7).
17.Yu-qing Liu, Hai-yan Wang, Shan-shan Li, Yan-yan Zhang, Xu Cheng, Wen-sheng Xiang*, Xiang-jing Wang*. Engineering of primary metabolic pathways for titer improvement of milbemycins in Streptomyces bingchenggensis. Appl Microbiol Biotechnol. 2021 Mar; 105 (5).
18.Li-yang Chu#, Shan-shan Li#, Zhuo-xu Dong, Yan-yan Zhang, Pin-jiao Jin, Lan Ye, Xiang-jingWang*，Wen-sheng Xiang*. Mining and engineering exporters for titer improvement of macrolide biopesticides in Streptomyces. Microb Biotechnol. 2021 Aug; 15 (4).
19.Xiao-yan Yu, Jing Zhang, Xue Zhang, Xi-lang Yang, Xi Xu, Jia-ying Lin, Hui Bing, Xiang-jing Wang, Jun-wei Zhao*, Wen-sheng Xiang*. Identification and Pathogenicity of Fungi Associated with Leaf Spot of Muskmelon in Eastern Shandong Province. China. Plant Dis. 2021 Oct 13.
20.Xi Xu#, Li Zhang#, Xi-lang Yang, Han-shui Cao, Jing-jing Li, Peng Cao, Li-feng Guo, Xiang-jing Wang, Jun-wei Zhao*, Wen-sheng Xiang*. Alternaria spp. associated with leaf blight of maize in Heilongjiang Province, China. Plant Dis, 2021 Sep 02.
21.Zhi-yin Yu, Hao Jiang, Li Wang, Feng-Xian Yang, Jian-Ping Huang, Chong-xi Liu, Xiao-wei Guo, Wen-sheng Xiang*,ShengXiong Huang*. Dimeric Pimprinine Alkaloids From Soil-Derived Streptomyces sp. NEAU-C99. Front Chem. 2020 Feb 18;8:95.
22.Hai-yan Wang, Xu Cheng, Yu-qing Liu, Shan-shan Li, Yan-yan Zhang, Xiang-jing Wang*, Wen-sheng Xiang*. Improved milbemycin production by engineering two Cytochromes P450 in Streptomyces bingchenggensis. Appl Microbiol Biotechnol. 2020 Apr;104(7).
23.Pin-jiao Jin, Shan-shan Li, Yan-yan Zhang, Li-yang Chua, Hai-rong He, Zhuo-xu Dong, Wen-sheng Xiang*. Mining and fine-tuning sugar uptake system for titer improvement of milbemycins in Streptomyces bingchenggensis. Synth Syst Biotechnol. 2020 Jul 14;5(3).
24.Hui Liu, Yan-yan Zhang, Shan-shan Li, Jia-bin Wang, Xiang-jing Wang*, Wen-sheng Xiang*. Elucidation of the Activation Pathways of ScyA1/ScyR1, an Aco/ArpA-Like System That Regulates the Expression of Nemadectin and Other Secondary Metabolic Biosynthetic Genes. Front Bioeng Biotechnol. 2020 Nov 3;8.
25.Xiao-wei Guo, Ji-dong Wang, Can Su, Chong-xi Liu, Xiao-yan Ma, Zhi-yin Yu, Jian-song Li, Xiang-jing Wang, Wen-sheng Xiang*, Sheng Xiong Huang*. unique spiro-β-triazinedione-γ-hydantoin type alkaloid with antiviral activity against tobacco mosaic virus from Streptomyces gamaensis. Organic Chemistry Frontiers. 2019(6)18.
26.Yue-ming Shan, Chang-long Shu, Kang-lai He, Xue Cheng, Li-li Geng, Wen-sheng Xiang*, and Jie Zhang*. Characterization of a novel insecticidal protein Cry9Cb1 from Bacillus thuringiensis. J Agric Food Chem. 2019 ,67(13).
27.Chuang Li, Hai-rong He, Jia-bin Wang, Hui Liu, Hai-yan Wang, Ya-jie Zhu, Xiang-jing Wang, Yan-yan Zhang*, Wen-sheng Xiang*. Characterization of a LAL-type regulator NemR in nemadectin biosynthesis and its application for increasing nemadectin production in Streptomyces cyaneogriseus. SCIENCE CHINA (Life Sciences), 2019,62 (3).
28.Hai-rong He, Lan Ye, Chuang Li, Hai-yan Wang, Xiao-wei Guo, Xiang-jing Wang, Yan-yan Zhang*,Wen-sheng Xiang*. SbbR/SbbA, an Important ArpA/AfsA-Like System, Regulates Milbemycin Production in Streptomyces bingchenggensis. Front Microbiol. 2018 May 23;9.
29.Wei Song, Li-ping Duan, Jun-wei Zhao, Shan-wen Jiang, Xiao-wei Guo, Wen-sheng Xiang*, Xiang-jing Wang*. Kribbella monticola sp. nov., a novel actinomycete isolated from soil. Int J Syst Evol Microbiol. 2018 Nov;68(11).
30.Dong-mei Li, Hao Jiang, Li-yuan Han, Yuan-yuan Li, Jun-wei Zhao, Shan-wen Jiang, Xiang-jing Wang*, Wen-sheng Xiang*. Lentzea terrae sp. nov., isolated from soil and an emended description of Lentzea soli. Int J Syst Evol Microbiol. 2018, 68(11).
31.Yuan-yuan Tian, Chuan-yu Han, Jun-wei Zhao, Hao-ran Shi, Jiang-mei-hui Hu, Shan-wen Jiang, Xiao-yang Han, Xiang-jing Wang*, Wen-sheng Xiang*. Streptomyces triticisoli sp. nov., a novel actinomycete isolated from rhizosphere soil of wheat (Triticum aestivum L.). Int J Syst Evol Microbiol. 2018,68(10).
