农药系

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姓名:刘重喜

职称: 教授

学科领域:农药学

研究方向:微生物天然产物农药

邮箱: liuchongxi@neau.edu.cn

个人简历

学习经历:

黑龙江省高层次人才(D类),黑龙江省植物保护专业技术领军人才梯队后备带头人,黑龙江省普通本科高等学校青年创新人才,东农学者计划“学术骨干”和“青年才俊”,黑龙江省基础研究领域专家,黑龙江省科协优秀青年科技人才,国家自然科学基金项目通讯评审专家、中国博士后科学基金评审专家、教育部学位论文通讯评审专家。主要从事“特境微生物新颖代谢产物发现、生物合成机制及作用机理研究”。主持国家自然科学基金(2项),国家重点研发项目子课题等14项;在Nat. Commun、Food Chemistry、J Agric. Food Chem、J. Nat. Prod、Phytopathology、中国科学等期刊发表研究论文130余篇研究;获美国化学会农用化学品部2023年杰出研究工作论文奖。获2014,2018,2021,2023年黑龙江省科学技术奖一等奖(第二完成人1项)和中国农药工业协会科学技术奖一等奖1项(第二完成人)。


学习经历:

2002.09-2006. 07:东北农业大学生命科学学院,工学学士;

2007. 09-2010. 07:东北农业大学生命科学学院,理学硕士;

2010. 09-2013. 07:东北农业大学生命科学学院,理学博士


工作经历:

2013.09 -2015.09,东北农业大学生命科学学院,讲师;

2015.09 -2022.12,东北农业大学生命科学学院,副教授;

2022.12 - 2024.09,东北农业大学植物保护学院,副教授;

2024.09–至今,东北农业大学植物保护学院,教授;

2013.11 -2018.11,东北农业大学农学院,博士后;

2015.12 -2020.12,中科院昆明植物研究所,高级访问学者

教学工作

授课情况:

本科生课程:《农业微生物学》《农业微生物学实验》

研究生课程:《绿色农药创制及靶标研究现状》《农业微生物分类》《生物农药的创新与研发》

科研工作

科研项目:

1.国家自然科学基金面上项目“新型防治小麦赤霉病杀菌剂福临霉素分子靶标的鉴定及作用机制研究”(32372595),2024.1-2027.12,50万元,主持

2.国家自然科学基金青年项目“拟黑多刺蚁共生放线菌的种群组成及其代谢新活性化合物研究”(31500010),2016. 01-2018. 12,24万元,主持

3.国家重点研发计划项目子课题“新型生物农药分子创制与产业化-微生物源农药新活性化合物的挖掘及生物合成机制研究”(2023YFD1700700),2023.12-2027.12,50万元,主持

4.黑龙江省青年科学基金“马陆共栖放线菌的分离、鉴定及其代谢产物研究”(QC2014C03),2014. 01-2016. 12,10万元,主持

5.中国博士后科学基金“大豆疫霉侵染后大豆根菌群变化及特异菌群代谢产物研究”(2014M561320),2014.03-2016.03,5万元,主持。

6.黑龙江省博士后科学基金“16S rRNA宏基因组分析疫霉侵染后大豆根内特异微生物群及其活性产物研究”(LBH-Z14027),2014.6-2016.6,10万元,主持。

7.黑龙江省教育厅科学技术项目“虫生放线菌的分离及其代谢产物研究”(12541001),2014.01-2016.12,3万元,主持

8.黑龙江省普通高等学校青年创新人才项目“日本弓背蚁共生放线菌的种群组成及其代谢活性产物研究”(UNPYSCT-2016153),2016.03-2019.03,10万元,主持

9.东北农业大学“学术骨干”项目“蚂蚁共生新菌Streptomyces sp. 1H-SSA4的活性产物分离及其生物合成途径研究”(17XG17),2017.10-2020.10,10万元,主持

10.东北农业大学“青年才俊”项目“日本弓背蚁共生放线菌筛选、鉴定及新活性化合物的发现”(14QC02),2015.1-2016.12, 6万元,主持

论文著作:

1.Zhiyan Wang, Congting Gao, Rajamanikandan Sundarraj, Dongxiao Shi, Zhe Ni, Jun-An Ma, Xiangjing Wang, Wensheng Xiang, Zhiguang Yuchi*, Chongxi Liu*Discovery of DNA gyrase as a promising target against phytopathogenic bacteria. J Agric Food Chem, 2026, 74(1), 930–940. (IF: 6.2,一区TOP)

2.Gengxin Zuo, Yuxuan Han, Qingyan Dong, Wentian Lu, Congting Gao, Na Zhao, Shuanghe Liu, Guoquan Fan, Chongxi Liu*, Wensheng Xiang*. Antifungal activity and mechanism of volatile organic compounds produced by Bacillus siamensis NEAU-ZGX24 against Botrytis cinerea. Microbiological Research. 2025, 299: 128265. (IF: 6.9,一区TOP)

3.Peng Sun, Wenhui Yin, Chengcheng Jiang, Wentian Lu, Tianhe Liu, Yiyi Shao, Chongxi Liu*, Jie Chen, Wensheng Xiang*, Xiangjing Wang*. Novel plant growth regulator guvermectin promotes root development by modulating auxin signaling. J Agric Food Chem, 2025, 73: 15155−15164. (IF: 6.2,一区TOP)

4.Hui Bing, Jinzhao Gu, Banghua Xia, Xinyu Kong, Yanfang Luo, Xiangjing Wang, Chongxi Liu*, Junwei Zhao*, Wensheng Xiang*. Endophytic fungus Stagonosporopsis ajaci NEAU-BLH1 from Adonis amurensis enhances seed germination under low-temperature stress and increases grain yield in direct-seeded rice. Microbiological Research. 2025, 295: 128111. (IF: 6.9,一区TOP)

5.Chongxi Liu, Manman Zhang, Lei Li, Xiangjing Wang, Shanshan Li*, Wensheng Xiang*. Development and application of the novel plant growth regulator guvermectin: A Perspective. J Agric Food Chem. 2024,72:8365-8371. (IF: 6.2,一区TOP)

6.Banghua Xia, Qirui Hao, Shuqun Xue, Hui Bing, Junfei Yu, Dandan Zhao, Congting Gao, Yixiao Ge, Chongxi Liu*. Geographical region traceability of wild topmouth culter (Culter alburnus) from Xingkai Lake based on muscle quality and aroma profiles. Food Chemistry, 2024, 438: 137979 (IF: 9.8,一区TOP).

7.Chongxi Liu, Chenxu Li, Hui Bing, Junwei Zhao, Lei Li, Peng Sun, Tingting Li, Dandan Du, Junlei Zhao, Xiangjing Wang*, Wensheng Xiang*. Integrated physiological, transcriptomic and metabolomic analysis reveals the mechanism of guvermectin promoting seed germination in direct-seeded rice under chilling stress.J Agric Food Chem.2023, 71: 7348-7358.(IF: 6.2,一区TOP)

8.Chongxi Liu, Lu Bai, Peng Cao, Shanshan Li, Sheng-Xiong Huang, Jidong Wang,Lei Li,Ji Zhang, Junwei Zhao, Jia Song, Peng Sun, Yanyan Zhang, Hui Zhang, Xiaowei Guo, Xilang Yang, Xinqiu Tan,Wende Liu*,Xiangjing Wang*,Wensheng Xiang*. Novel plant growth regulator guvermectin from plant growth-promoting rhizobacteriaboosts biomass and grain yield in rice.J Agric Food Chem. 2022,70: 16229-16240. (IF: 6.2,一区TOP)

9.Chuanyu Han, Zhiyin Yu, Yuting Zhang, Zhiyan Wang, Junwei Zhao, Sheng-Xiong Huang, Zhonghua Ma,Ziyue Wen, Chongxi Liu*, Wensheng Xiang*.Discovery of frenolicin B as potential agrochemical fungicide for controlling Fusarium head blight on wheat.J.Agric.Food.Chem. 2021, 69: 2108-2117.(IF: 6.2,一区TOP)

10.Chongxi Liu, Ji Zhang,Xiangjing Wang, Pingting Qian,Jidong Wang, Yamei Gao, Yijun Yan, Shuzhen Zhang, Pengfei Xu, Wenbin Li, Wensheng Xiang*.Antifungal activity of borrelidin produced by a Streptomyces strain isolated from soybean.J. Agric. Food. Chem. 2012, 60: 1251–1257. (IF: 6.2,一区TOP)

11.Zhiyan Wang, Congting Gao, Jingquan Yang, Rui Du, Fanli Zeng, Hui Bing, Banghua Xia, Yue Shen*, Chongxi Liu*. Endophytic Streptomyces sp. NEAU-ZSY13 from the leaf of Perilla frutescens, as a promising broad-spectrum biocontrol agent against soil-borne diseases. Front. Microbiol. 2023, 14:1243610 (IF: 4.5).

12.Congting Gao, Zhiyan Wang, Chengqin Wang, Jingquan Yang, Rui Du, Hui Bing, Wensheng Xiang, Xiangjing Wang*, Chongxi Liu*. Endophytic Streptomyces sp. NEAU-DD186 from moss with broad-spectrum antimicrobial activity: Biocontrol potential against soil-borne diseases and bioactive components. Phytopathology® 2024, 114: 340-347 (IF: 3.1).

13.Rui Du, Hui Bing, Wentian Lu, Congting Gao, Fanxue Kong, Hongtu Wang, Yue Shen, Chongxi Liu*, Wensheng Xiang*. Streptomyces adonidis sp. nov., a novel actinomycete strain with antifungal activity isolated from the root of Adonis amurensis Regel. Antonie van Leeuwenhoek. 2025, 118: 62. (IF: 1.8)

14.Chongxi Liu, Zhiyan Wang, Yin Chen, Yijun Yan, Lei Li, Yong-Jiang Wang, Lu Bai, Shanshan Li,Yanyan Zhang,Xiangjing Wang*, Sheng-Xiong Huang*, Wensheng Xiang*. Guvermectin biosynthesis revealing the key role of aphosphoribohydrolaseand structural insight into the active glutamate of anoncanonical adenine phosphoribosyltransferase. ACS Chem Biol. 2023, 18: 102-111.(IF:3.8)

15.Zhiyan Wang, Zhiyin Yu, Junwei Zhao, Xiaoxin Zhuang, Peng Cao, Xiaowei Guo, Chongxi Liu*, Wensheng Xiang*. Community composition, antifungal activity and chemical analyses of ant-derived actinobacteria. Front. Microbiol. 2020,11:201.(Q2,IF:4.5)

16.Xiaoxin Zhuang, Zhiyan Wang, Chenghui Peng, Can Su, Congting Gao, Yongjiang Wang, Shengxiong Huang*, Chongxi Liu*. Characterization of Streptomyces piniterrae sp. nov. and identification of the putative gene cluster encoding the biosynthesis of heliquinomycins. Microorganisms.2020, 8:495.(IF: 4.2)

17.Zhiyin Yu, Chuanyu Han, Bing Yu, Junwei Zhao, Yijun Yan, Shengxiong Huang, Chongxi Liu*, Wensheng Xiang*. Taxonomic characterization, and secondary metabolite analysis of Streptomyces triticiradicis sp. nov.:anovel actinomycete with antifungal activity. Microorganisms.2020, 8:77.(IF: 4.2)

18.Xiaoxin Zhuang, Congting Gao, Chenghui Peng, Zhiyan Wang, Junwei Zhao, Yue Shen*, Chongxi Liu*. Characterization of a novel endophytic actinomycete, Streptomyces physcomitrii sp. nov., and its biocontrol potential against Ralstonia solanacearum on tomato. Microorganisms.2020, 8:2025.(IF: 4.2)

19.Chongxi Liu, Xiaoxin Zhuang, Zhiyin Yu, Zhiyan Wang, Yongjiang Wang, Xiaowei Guo, Wensheng Xiang*, Shengxiong Huang*. Community structures and antifungal activity of root-associated endophytic actinobacteria of healthy and diseased soybean. Microorganisms.2019, 7:243.(Q3,IF: 4.2)

20.Chongxi Liu, Xiangjing Wang, Yijun Yan, Jidong Wang, Bo Zhang, Ji Zhang, Wensheng Xiang. Streptomyces heilongjiangensis sp. nov., a novel actinomycete that produces borrelidin isolated from the root surface of soybean (Glycine max (L.) Merr). Int.J.Syst.Evol.Microbiol. 2013, 63:1030-1036.(IF:2)

21.Chongxi Liu, Xiangjing Wang, Junwei Zhao, Qianfeng Liu, Liang Wang, Xuejiao Guan, Hairong He, Wensheng Xiang. Streptomyces harbinensis sp. nov., a novel endophytic actinomycete that produces ikarugamycin isolated from soybean root (Glycine max (L.) Merr). Int.J.Syst.Evol.Microbiol. 2013, 63:3579-3584.(IF:2)

22.Chongxi Liu, Xuejiao Guan, Shurui Wang, Junwei Zhao, Haiyan Wang, Hairong He, Wensheng Xiang*, Xiangjing Wang*. Saccharothrix carnea sp. nov., a novel actinobacterium isolated from soil. Int.J.Syst.Evol.Microbiol.2014, 64:4033-4037. (IF:2)

23.Chongxi Liu, Junwei Zhao, Xuejiao Guan, Lianjie Li, Wenbin Li, Xiangjing Wang, Wensheng Xiang*. Catellatospora aurea sp. nov., a novel actinomycete isolated from soil. Antonie van Leeuwenhoek.2014, 106:1185-1190.(IF:1.8)

24.Chongxi Liu, Xuejiao Guan, Pinjiao Jin, Jinmeng Li, Yao Li, Lianjie Li, Ying Zhou, Yue Shen, Xiangjing Wang, Wensheng Xiang*. Dactylosporangium cerinum sp. nov., a novel actinobacterium isolated from the rhizosphere of Pinus koraiensis Sieb. et Zucc. Antonie van Leeuwenhoek.2015, 108: 191-199.(IF:1.8)

25.Chongxi Liu, Xuejiao Guan, Yao Li, Wenchao Li, Lan Ye, Xiangxing Kong, Jia Song, Xiangjing Wang*, Wensheng Xiang*. Nocardia camponoti sp. nov., a novel actinomycete isolated from the head of an ant (Camponotus japonicas Mayr). Int.J.Syst.Evol.Microbiol. 2016, 66: 1900-1905.(IF:2)

26.Chongxi Liu, Yao li, Lan Ye, Junwei Zhao, Chenyu Piao, Zhilei Li, Jiansong Li, Wensheng Xiang*, Xiangjing Wang*. Actinocorallia lasiicapitis sp. nov., a novel actinomycete isolated from the head of an ant (Lasius fuliginosus L). Int.J.Syst.Evol.Microbiol. 2016, 66: 2172-2177.(IF:2)

27.Yao li, Lan Ye, Xiangjing Wang, Junwei Zhao, Zhaoxu Ma, Kai Yan, Wensheng Xiang*, Chongxi Liu*. Streptomyces camponoticapitis sp. nov., a novel actinomycete isolated from the head of an ant (Camponotus japonicus Mayr). Int.J.Syst.Evol.Microbiol. 2016, 66: 3855-3859.(IF:2)

28.Chongxi Liu, Lan Ye, Yao Li, Shanwen Jiang, Hui Liu, Kai Yan, Wensheng Xiang*, Xiangjing Wang*. Streptomyces kronopolitis sp. nov., a novel actinomycete that produces phoslactomycins isolated from a millipede (Kronopolites svenhedind Verhoeff). Int.J.Syst.Evol.Microbiol. 2016, 66:5352-5357.(IF:2)

29.Chongxi Liu, Lu Bai, Lan Ye, Junwei Zhao, Kai Yan, Wensheng Xiang*, Xiangjing Wang*. Nocardia lasii sp. nov., a novel actinomycete isolated from the cuticle of an ant (Lasius fuliginosus L). Antonie van Leeuwenhoek.2016, 109: 1513-1520.(IF:2)

30.Chongxi Liu, Shuanghe Liu, Junwei Zhao, Ji Zhang, Xiangjing Wang, Jiansong Li, Jidong Wang*, Wensheng Xiang*. A new spectinabilin derivative with cytotoxic activity from ant-derived Streptomyces sp. 1H-GS5. J.Asian.Nat.Prod.Res.2017, 19:924-929.(IF: 1.3)

31.Chongxi Liu, Chuanyu Han, Shanwen Jiang, Xueli Zhao, Yuanyuan Tian, Kai Yan, Xiangjing Wang*, Wensheng Xiang*. Streptomyces lasii sp. nov., a novel actinomycete with antifungal activity isolated from the head of an ant (Lasius flavus). Curr.Microbiol.2018, 75:353-358.(IF: 2.6)

32.Lan Ye, Shanshan Zhao, Yao Li, Shanwen Jiang, Yue Zhao, Jinmeng Li, Kai Yan, Xiangjing Wang, Wensheng Xiang*, Chongxi Liu*. Streptomyces lasiicapitis sp. nov., a novel actinomycete that produces kanchanamycin isolated from the head of an ant (Lasius fuliginosus L.). Int.J.Syst.Evol.Microbiol. 2017, 67:1529-1534.(IF:2)

33.Tingting Cao, Shan Mu, Chang Lu, Shanshan Zhao, Dongmei Li, Kai Yan, Wensheng Xiang*, Chongxi Liu*. Streptomyces amphotericinicus sp. nov., an amphotericin-producing actinomycete isolated from the head of an ant (Camponotus japonicus Mayr). Int.J.Syst.Evol.Microbiol. 2017, 67:4967-4973.(IF:2)

34.Shanwen Jiang, Chenyu Piao, Yang Yu, Peng Cao, Chenxu Li, Fan Yang, Mutong Li, Wensheng Xiang*, Chongxi Liu*. Streptomyces capitiformicae sp. nov., a novel actinomycete producing angucyclinone antibiotics isolated from the head of Camponotus japonicus Mayr. Int.J.Syst.Evol.Microbiol. 2018, 68:118-124.(IF:2)

35.Xiaoxin Zhuang, Chenghui Peng, Zhiyan Wang, Junwei Zhao, Yue Shen, Chongxi Liu*, Wensheng Xiang*. Actinomadura physcomitrii sp. nov., a novel actinomycete isolated from moss [Physcomitrium sphaericum (Ludw) Fuernr]. Antonie van Leeuwenhoek.2020, 113: 677-685.(IF:1.8)

36.Chenghui Peng, Xiaoxin Zhuang, Zhiyan Wang, Congting Gao, Junwei Zhao, Jia Song, Chongxi Liu*, Yue Shen*. Nonomuraea typhae sp. nov., a novel endophytic actinomycete isolated from the root of cattail pollen (Typha angustifolia L.). Int.J.Syst.Evol.Microbiol. 2020, 70: 3845-3851.(IF:2)

37.Chenghui Peng, Xiaoxin Zhuang, Congting Gao, Zhiyan Wang, Junwei Zhao, Sheng-Xiong Huang, Chongxi Liu*, Wensheng Xiang*. Streptomyces typhae sp. nov., a novelendophyticactinomycete with antifungal activity isolated the root of cattail (Typha angustifolia L.). Antonie van Leeuwenhoek.2021, 114: 823-833.(IF:1.8)

38.Hongmin Chen, Tingting Cao, Teng Wang, Congting Gao, Jingquan Yang, Qingyan Dong, Yue Shen*, Chongxi Liu*. Mumia quercus sp. nov., isolated from the root of Quercus variabilis.Int J Syst Evol Microbiol.2023, 73:005776. (IF:2)

39.Teng Wang, Congting Gao, Hongmin Chen, Jingquan Yang, Rui Du, Gengxin Zuo, Junwei Zhao, Wensheng Xiang*, Chongxi Liu*. Sphaerisporangium perillae sp. nov., isolated from the root of Perilla frutescens (Linn.) Britt.Int J Syst Evol Microbiol. 2023,73(4): 005773. (IF:2)

40.Chongxi Liu, Feiyu Jia, Wensheng Xiang. Xiangella. Bergey's Manual of Systematics of Archaea and Bacteria, 2016, DOI: 10.1002/9781118960608.gbm01321.

41.Chongxi Liu, Xuejiao Guan, Wensheng Xiang. Baia. Bergey's Manual of Systematics of Archaea and Bacteria, 2018, DOI: 10.1002/9781118960608.gbm01629.

42.刘重喜,宋佳,王相晶,向文胜.植物招募防御微生物与植物保护,中国科学:生命科学,2016,46: 1-8.

科研成果

专利:

1.一种具有广谱抗菌活性的链霉菌及其生物菌肥与应用.中国,2024,专利号:ZL202310413734.1(排名第1)

2.杀疮痂菌素在抑制马铃薯疮痂病病原菌及防治马铃薯疮痂病中的应用.中国,2024,申请号:202411879528.0(排名第1)

3.一株可产生挥发性广谱抗菌物质的暹罗芽孢杆菌及其应用.中国,2024,申请号:202411912124.7(排名第1)

4.福临霉素在抑制引起植物病害的病原真菌活性中的应用,中国,2021,专利号:ZL202010026658.5(排名第2)

5.一株链霉菌及其应用.中国,2022,专利号:ZL201910189570.2(排名第2)

6.一种大环内酯类化合物及其制备方法和应用,中国,2015,专利号:ZL2013101623698.8(排名第2)

7.一种新吡喃酮类化合物及其制备方法和应用,中国,2018年,专利号:ZL201610279375.5(排名第2)

8.谷维菌素生物合成基因、基因簇、蛋白及其应用以及制备谷维菌素的方法.中国,2022,申请号:202210605901.8(排名第2)

9.具有植物生长调节功能的组合物及其制备方法与应用.中国,2022,申请号:202211584217.2(排名第2)

10.谷维菌素作为杀菌剂的应用.中国,2023,申请号:202311161585.0(排名第3)

11.一种以丰枝素为有效成分的植物生长调节剂及其应用.中国,2025,申请号:202510303891.6(排名第3)

12.一种含有丰枝素的农药组合物及其应用.中国,2025,申请号:202510303894.X(排名第3)

13.一种含有丰枝素的农药组合物及其应用.中国,2025,申请号:202510303894.X(排名第3)

14.一种噻唑-吡啶杂合类化合物及其制备方法与应用.中国,2023,专利号:ZL202210687577.9(排名第4)

15.勃利霉素对大豆疫霉根腐病的防治作用,中国,2015,专利号:ZL201180069377.7(排名第4)


获奖:

1.美国化学会农用化学品部杰出研究工作论文奖,Novel Plant Growth Regulator Guvermectin from Plant Growth-Promoting Rhizobacteria Boosts Biomass and Grain Yield in Rice,2023年,排名1

2.黑龙江省科学技术奖一等奖,原创新型微生物天然产物植物生长调节剂谷维菌素及产业化应用,2024,排名2

3.中国农药工业协会科学技术奖一等奖,原创新型微生物天然产物植物生长调节剂谷维菌素及产业化应用,2024,排名2

4.黑龙江省科学技术奖一等奖,链霉菌天然产物农药代谢机制认知和高效生物制造,2021,排名6

5.黑龙江省科学技术奖一等奖,重要功能农业微生物资源研究及产业化应用,2021,排名5

6.黑龙江省科学技术奖一等奖,高效筛选农用抗生素体系构建及产多拉菌素新菌株发现与产业化,2014,排名7